Pelvic Factor

Normal Events

Pelvic Factor Detection

Pelvic Abnormalities

Clinical Evaluation

Treatment Options

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Dr Eric Daiter is a nationally recognized expert in Reproductive Endocrinology and Infertility who has proudly served patients at his office in New Jersey for 20 years. If you have questions or you just want to find a caring infertility specialist, Dr Eric Daiter would be happy to help you (in the office or on the telephone). It is easy, just call us at 908 226 0250 to set up an appointment (leave a message with your name and number if we are unable to get to the phone and someone will call you back).


"I always try to be available for my patients since I do understand the pain and frustration associated with fertility problems or endometriosis."


"I understand that the economy is very tough and insurance companies do not cover a lot of the services that might help you. I always try to minimize your out of pocket cost while encouraging the most successful and effective treatments available."

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Fertilized Human Egg with Multiple Pronuclei

A fertilized human egg with multiple pronuclei and fragments outside the plasma membrane (look like multiple polar bodies). These abnormal embryos occurred following intracytoplasmic sperm injection (ICSI), where only one sperm is injected directly into the eggs cytoplasm. Therefore, polyspermic fertilization was not possible. The percentage of 3 pronuclear zygotes (fertilized eggs) after ICSI is generally less than 10%.

The cause of multipronuclear fertilized eggs following ICSI is often unclear. It is thought that most of these abnormalities occur due to failure to extrude the second polar body. These mistakes in chromosome segregation during the second meiotic division may be caused by the (traumatic) ICSI procedure or may reflect an inherently abnormal egg.

The mechanism resulting in the presence of more than 3 pronuclei or more than 2 polar bodies is also not clear, but may be due to duplication or fragmentation. It is also (theoretically) possible that the egg that was fertilized was digynic (contained a pair of each of the 23 chromosomes rather than one of each of these 23 chromosomes) or binuclear (had two rather than one nucleus) at the time of ICSI, which would then result in three pronuclei after fertilization.

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